Motonori Tsuji

2-105-14 Takasu

Misato-shi, Saitama 341-0037, JAPAN

Institute of Molecular Function President (2003 - )

Osaka University. Invited Faculty (2024 - )

Yokohama National University. Part-time  Lecturer (2021 - )

Tokyo Medical and Dental University. Part-time Lecturer (2017 - 2025 )

Graduate School of Medicine, Chiba University. Part-time Lecturer (2007)

Graduate School of Pharmaceutical Sciences, University of Tokyo. Research Assistant (1997-2001)

E-mail: motonori_#_molfunction.com (Please replace "_#_" with "@")

Fax +81 48 956 6985

Researcher Information

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Academic Products

Homology Modeling Professional for HyperChem, Virtual Screening System, Docking Study with HyperChem, AutoDock Vina In Silico Screenings Interface, ONIOM Interface for Receptor, Gaussian Interface for HyperChem, Ab Initio Protein 3D Modeling, Protein Secondary Structure Prediction programs.

Contribution to novel coronavirus (SARS-CoV-2, 2019-nCoV) using the computer-aided drug design techniques

I'm ready to provide the research results for the antibody design technique for novel coronavirus envelope glycoprotein and the virtual screenings results for main protease.

Please contact me if you need these results.

Articles

Major  Publications

Major Publications and Products (Since 2000)

YouTube Contents (Education, Research, Science Technology, Society Contributions)

2025

Kazuaki Sekimoto, Hanaka Kinjo, Mizuki Murakami, Akiko Ohashi, Rei Fukui, Eri Nagasaki-Maeoka, Yoshinori Inagaki, Tadateru Takayama, Kazuhiro Ikeda, Ken-ichi Takayama, Satoshi Inoue, Motonori Tsuji, Joe Otsuki, Kyoko Fujiwara. Effects of the number of ethylene glycol units on the efficacy of novel complex I inhibitor 9bw. Biochemistry and Biophysics Reports, 42, 101981, 2025.

Wataru Fujii, Osamu Yamazaki, Daigoro Hirohama, Ken Kaseda, Emiko Kuribayashi-Okuma, Motonori Tsuji, Makoto Hosoyamada, Yuta Kochi, Shigeru Shibata. Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12. J Clin Invest. https://doi.org/10.1172/JCI186633.

2024

Shin Matsumura, Ayano Shida, Moeno Tsuchii, Mika Wada, Jimmy Charneau, Motonori Tsuji, Keiji Hasumi, Eriko Suzuki. Intradomain Allosteric Regulation of Soluble Epoxide Hydrolase by Its Substrates.
Int. J. Mol. Sci., 25, 13496, 2024.

Jun-ichi Wachino, Wanchun Jin, Chihiro Norizuki, Kouji Kimura, Motonori Tsuji, Hiromasa Kurosaki, Yoshichika Arakawa. Hydroxyhexylitaconic acids as potent IMP-type metallo-β-lactamase inhibitors for controlling carbapenem resistance in Enterobacterales. Microbiology Spectrum, 12, 2024. https://doi.org/10.1128/spectrum.02344-23

2023

Bunki Natsumoto, Hirofumi Shoda, Yasuo Nagafuchi, Mineto Ota, Takashi Okumura, Yumi Horie, Tomohisa Okamura, Kazuhiko Yamamoto, Motonori Tsuji, Makoto Otsu, Hideki Taniguchi, Keishi Fujio. Functional evaluation of rare OASL variants by analysis of SLE patient-derived iPSCs. Journal of Autoimmunity, 139, 103085, 2023. https://doi.org/10.1016/j.jaut.2023.103085

2022

Motonori Tsuji. Virtual Screening and quantum chemistry analysis for SARS-CoV-2 RNA-dependent RNA polymerase using the ChEMBL database: Reproduction of the remdesivir-RTP and favipiravir-RTP binding modes obtained from cryo-EM experiments with high binding affinity. Int. J. Mol. Sci., 23, 11009, 2022.

2021

Riho Tateyama-Makino, Mari Abe-Yutori, Taku Iwamoto, Kota Tsutsumi, Motonori Tsuji, Satoru Morishita, Kei Kurita, Yukio Yamamoto, Eiji Nishinaga, Keiichi Tsukinoki. The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro. PLOS ONE, 16, e0257705-e0257705, 2021.

2020

Uranan Tumkosit, Uamporn Siripanyaphinyo, Naokazu Takeda, Motonori Tsuji, Yusuke Maeda, Kriangsak Ruchusatsawat, Tatsuo Shioda, Hiroto Mizushima, Prukswan Chetanachan, Pattara Wongjaroen, Yoshiharu Matsuura, Masashi Tatsumi, Atsushi Tanaka. Anti-Chikungunya Virus Monoclonal Antibody Inhibiting Viral Fusion and Release. J Virol. 2020. DOI: 10.1128/JVI.00252-20.

Motonori Tsuji.Potential Anti-SARS-CoV-2 Drug Candidates Identified through Virtual Screening of the ChEMBL Database for Compounds that Target the Main Coronavirus Protease. FEBS Open Bio, 2020. DOI:10.1002/2211-5463.12875.

(Selected to the Most Read Article in FEBS Open Bio.)

Wei Yang, Zaiqiang Yu, Mari Chiyoya, Xu Liu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa, Motonori Tsuji, Kazuhiko Seya. Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR. J. Pharmacol. Exp. Ther., 372, 277-284, 2020.

2019

2018

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual 2, Institute of Molecular Function, Saitama, Japan, pp1-34, 2018. ISBN: 978-4-9902513-5-2.

Motonori Tsuji. Docking Study with HyperChem Manual 2, Institute of Molecular Function, Saitama, Japan, pp1-54, 2018. ISBN: 978-4-9902513-4-5.

Motonori Tsuji. Virtual Screening System, Revision H1, Institute of Molecular Function, Saitama, Japan, 2018.

Motonori Tsuji. Docking Study with HyperChem, Revision H1, Institute of Molecular Function, Saitama, Japan, 2018. 

Motonori Tsuji. AutoDock Vina In Silico Screenings Interface, Institute of Molecular Function, Saitama, Japanm 2018.

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision H1, Institute of Molecular Function, Saitama, Japan, 2018. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision H1, Institute of Molecular Function, Saitama, Japan, 2018. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision H1, Institute of Molecular Function, Saitama, Japan, 2018. 

2017

Motonori Tsuji.  Antagonist-Perturbation Mechanism for Activation Function-2 Fixed Motifs: Active Conformation and Docking Mode of Retinoid X Receptor Antagonists. J. Comput. Aided Mol. Des., 2017, 31, 577-585, DOI: 10.1007/s10822-017-0025-6. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision G1.2, Institute of Molecular Function, Saitama, Japan, 2017. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision G1.2, Institute of Molecular Function, Saitama, Japan, 2017. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision G1.2, Institute of Molecular Function, Saitama, Japan, 2017. 

Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika. Identifying the Receptor Subtype Selectivity of Retinoid X and Retinoic Acid Receptors via Quantum Mechanics. FEBS Open Bio., 2017, 7, 391-396, DOI: 10.1002/2211-5463.12188.

2016

 Motonori Tsuji. Virtual Screening System, Revision G1.1, Institute of Molecular Function, Saitama, Japan, 2016.

Motonori Tsuji. Docking Study with HyperChem, Revision G1.1, Institute of Molecular Function, Saitama, Japan, 2016. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision G1.1, Institute of Molecular Function, Saitama, Japan, 2016. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision G1.1, Institute of Molecular Function, Saitama, Japan, 2016. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision G1.1, Institute of Molecular Function, Saitama, Japan, 2016. 

2015

Motonori Tsuji. A Ligand-Entry Surface of the Nuclear Receptor Superfamily Consists of the Helix H3 of the Ligand-Binding Domain. J. Mol. Graph. Model., 2015, 62, 262-275. 

Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika. Docking Simulations Suggest that all-trans Retinoic Acid Could Bind to Retinoid X Receptors. J. Comput. Aided Mol. Des., 2015, 29, 975-988. 

Motonori Tsuji. Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: p Facial Stereoselectivity of Bicyclic and Tricyclic Olefins. Asian J. Org. Chem., 2015, 4, 659-673. 

(Chosen by Editor) 

Motonori Tsuji. Virtual Screening System, Revision G1, Institute of Molecular Function, Saitama, Japan, 2015.

Motonori Tsuji. Docking Study with HyperChem, Revision G1, Institute of Molecular Function, Saitama, Japan, 2015. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision G1, Institute of Molecular Function, Saitama, Japan, 2015. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision G1, Institute of Molecular Function, Saitama, Japan, 2015. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision G1, Institute of Molecular Function, Saitama, Japan, 2015. 

2014

 Motonori Tsuji. Virtual Screening System, Revision F3, Institute of Molecular Function, Saitama, Japan, 2014.

Motonori Tsuji. Docking Study with HyperChem, Revision F3, Institute of Molecular Function, Saitama, Japan, 2014. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision F3, Institute of Molecular Function, Saitama, Japan, 2014. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision F3, Institute of Molecular Function, Saitama, Japan, 2014. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision F3, Institute of Molecular Function, Saitama, Japan, 2014. 

Motonori Tsuji. Local Motifs Involved in the Canonical Structure of the Ligand-Binding Domain in the Nuclear Receptor Superfamily. J. Struct. Biol.,2014, 185,355-365. 

(Top 22th article downloaded for 90 days) 

2013

2012

Motonori Tsuji. Virtual Screening System, Revision F2, Institute of Molecular Function, Saitama, Japan, 2012.

Motonori Tsuji. Docking Study with HyperChem, Revision F2, Institute of Molecular Function, Saitama, Japan, 2012. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision F2, Institute of Molecular Function, Saitama, Japan, 2012. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision F2, Institute of Molecular Function, Saitama, Japan, 2012. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision F2, Institute of Molecular Function, Saitama, Japan, 2012. 

2011

2010

Motonori Tsuji. Virtual Screening System, Revision F1, Institute of Molecular Function, Saitama, Japan, 2010.

Motonori Tsuji. Docking Study with HyperChem, Revision F1, Institute of Molecular Function, Saitama, Japan, 2010. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision F1, Institute of Molecular Function, Saitama, Japan, 2010. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision F1, Institute of Molecular Function, Saitama, Japan, 2010. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision F1, Institute of Molecular Function, Saitama, Japan, 2010. 

Motonori Tsuji.  Homology Modeling Professional for HyperChem Reference, Institute of Molecular Function, pp1-22, 4th ed., 2010.

Motonori Tsuji. Docking Study with HyperChem Manual, Institute of Molecular Function, pp1-108, 5th ed., 2010.

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual, Institute of Molecular Function, pp1-133, 6th ed., 2010.

2009

Motonori Tsuji.  Homology Modeling Professional for HyperChem Reference, Institute of Molecular Function, 3th ed., 2009.

Motonori Tsuji. Docking Study with HyperChem Manual, Institute of Molecular Function, 4th ed., 2009.

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual, Institute of Molecular Function, 5th ed., 2009.

2008

Motonori Tsuji.  Homology Modeling Professional for HyperChem Reference, Institute of Molecular Function, 2nd ed., 2008.

Motonori Tsuji. Docking Study with HyperChem Manual, Institute of Molecular Function, 3th ed., 2008.

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual, Institute of Molecular Function, 4th ed., 2008.

Motonori Tsuji. Virtual Screening System, Revision E1 and E2, Institute of Molecular Function, Saitama, Japan, 2008.

Motonori Tsuji. Docking Study with HyperChem, Revision E1 and E2, Institute of Molecular Function, Saitama, Japan, 2008. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision E1 and E2, Institute of Molecular Function, Saitama, Japan, 2008. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision E1 and E2, Institute of Molecular Function, Saitama, Japan, 2008. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision E1 and E2, Institute of Molecular Function, Saitama, Japan, 2008. 

2007

Motonori Tsuji. Development of the Structure-based Drug Design System, HCHC and DSHC. Mol. Sci. 2007, 1, NP004. 

Motonori Tsuji.  Homology Modeling Professional for HyperChem Reference, Institute of Molecular Function, 1st ed., 2007.

Motonori Tsuji. Docking Study with HyperChem Manual, Institute of Molecular Function, 2nd ed., 2007.

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual, Institute of Molecular Function, 3th ed., 2007.

Motonori Tsuji. Virtual Screening System, Revision C1, C2, and D1, Institute of Molecular Function, Saitama, Japan, 2007.

Motonori Tsuji. Docking Study with HyperChem, Revision C1, C2, and D1, Institute of Molecular Function, Saitama, Japan, 2007. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision C1, C2, and D1, Institute of Molecular Function, Saitama, Japan, 2007. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision C1, C2, and D1, Institute of Molecular Function, Saitama, Japan, 2007. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision C1, C2, and D1, Institute of Molecular Function, Saitama, Japan, 2007. 

2006

Motonori Tsuji. Rational Drug Design for Organic Chemists. Institute of molecular Function, 2006. 

Motonori Tsuji. Seitaikoubunnshi niokeru Sougosayoubui no Yosokuhouhou. JP, Patent 2006-125188, 2006. 

Motonori Tsuji. Docking Study with HyperChem Manual, Institute of Molecular Function, 1st ed., 2006.

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual, Institute of Molecular Function, 2nd ed., 2006.

Motonori Tsuji. Virtual Screening System, Revision A2 and B1, Institute of Molecular Function, Saitama, Japan, 2006.

Motonori Tsuji. Docking Study with HyperChem, Revision A2 and B1, Institute of Molecular Function, Saitama, Japan, 2006. 

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision B1, Institute of Molecular Function, Saitama, Japan, 2006. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision B1, Institute of Molecular Function, Saitama, Japan, 2006. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision B1, Institute of Molecular Function, Saitama, Japan, 2006. 

2005

Motonori Tsuji. Homology Modeling Professional for HyperChem Manual, Institute of Molecular Function, 1st ed., 2005.

Motonori Tsuji. Homology Modeling Reference for HyperChem, Institute of Molecular Function, 1st ed., pp1-66, 2005.

Motonori Tsuji. Homology Modeling Professional for HyperChem, Revision A3, Institute of Molecular Function, Saitama, Japan, 2005. 

Motonori Tsuji. ONIOM Interface for Receptor, Revision A3, Institute of Molecular Function, Saitama, Japan, 2005. 

Motonori Tsuji. Gaussian Interface for Receptor, Revision A3, Institute of Molecular Function, Saitama, Japan, 2005. 

2004

Motonori Tsuji. Most Stable Conformation of the Cyclopropane Ring Attached at a Carbon Atom in a 1,2-Dicarba-closo-dodecaborane(12) System. J. Org. Chem., 2004, 69, 4063-4074.

2003

Motonori Tsuji. On Attempts at Generation of Carboranyl Carbocation. J. Org. Chem., 2003, 68, 9589-9597.

2002

Motonori Tsuji. Ab Initio Protein 3D Modeling, Saitama, Japan, 2002. 

Motonori Tsuji. Protein Secondary Structure Prediction, Saitama, Japan, 2002. 

2001

2000

Motonori Tsuji, Yukiko Koiso, Hiroyasu Takahashi, Yuichi Hashimoto, Yasuyuki Endo. Modulatos of Tumor Necrosis Factor a Production Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore. Biol. Pharm. Bull., 2000, 23, 513-516.

       Society Activities

Business Research Institute                                                            2008 -            Special Member

American Chemical Society                                                           2003 -            Regular Member

Japan Society for Retinoid Research                                              1994 -            Regular Member

Society Computer Chemistry, Japan                                              1994 -            Regular Member

The Pharmaceutical Society of Japan                                             1992 -            Regular Member

Japan Society for Bioscience, Biotechnology, and Agrochemistry   1990 - 1995

Pesticide Science Society of Japan                                                 1990 - 1995