Publications
Medicinal Chemistry & Bioorganic Chemistry
Nuclear Receptor Ligands
Toshihiko Tashima, Hiroyuki Kagechika, Motonori Tsuji, Hiroshi Fukasawa, Emiko Kawachi, Yuichi Hashimoto, Koichi Shudo. Polyenylidene Thiazolidine Derivatives with Retinoidal Activities. Chem. Pharm. Bull., 1997, 45, 1805-1813.
Kiminori Ohta, Motonori Tsuji, Emiko Kawachi, Hiroshi Fukasawa, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika. Potent Retinoid Synergists with a Diphenylamine Skeleton. Biol. Pharm. Bull., 1998, 21, 544-546.
Toru Iijima, Yasuyuki Endo, Motonori Tsuji, Emiko Kawachi, Hiroyuki Kagechika, Koichi Shudo. Dicarba-closo-dodecaboranes as a Pharmacophore. Retinoidal Antagonists and Potential Agonists. Chem. Pharm. Bull., 1999, 47, 398-404.
Masayuki Ebisawa, Hiroki Umemiya, Kiminori Ohta, Hiroshi Fukasawa, Emiko Kawachi, Ghislaine Christoffel, Hinrich Gronemeyer, Motonori Tsuji, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika. Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids. Chem. Pharm. Bull.,1999, 47, 1778-1786.
Wei Yang, Zaiqiang Yu, Mari Chiyoya, Xu Liu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa, Motonori Tsuji, Kazuhiko Seya. Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR. J. Pharmacol. Exp. Ther., 2020, 372, 277-284.
Virus Research
Uranan Tumkosit, Uamporn Siripanyaphinyo, Naokazu Takeda, Motonori Tsuji, Yusuke Maeda, Kriangsak Ruchusatsawat, Tatsuo Shioda, Hiroto Mizushima, Prukswan Chetanachan, Pattara Wongjaroen, Yoshiharu Matsuura, Masashi Tatsumi, Atsushi Tanaka. Anti-Chikungunya Virus Monoclonal Antibody Inhibiting Viral Fusion and Release. J. Virol. 2020.
Riho Tateyama-Makino, Mari Abe-Yutori, Taku Iwamoto, Kota Tsutsumi, Motonori Tsuji, Satoru Morishita, Kei Kurita, Yukio Yamamoto, Eiji Nishinaga, Keiichi Tsukinoki. The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro. PLOS ONE, 16, e0257705-e0257705, 2021.
Immunology
Others
Motonori Tsuji, Yukiko Koiso, Hiroyasu Takahashi, Yuichi Hashimoto, Yasuyuki Endo. Modulators of Tumor Necrosis Factor a Production Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore. Biol. Pharm. Bull., 2000, 23, 513-516.
Motonori Tsuji, Eiichi Kuwano, Tetsuya Saito, Morifusa Eto. Root Growth-promoting Activities of N-Acyl-L-proline Derivatives. Biosci. Biotech. Biochem., 1992, 56, 778-782.
Molecular Modeling (Rational Drug Design)
Motonori Tsuji*. Rational Drug Design for Organic Chemists. Institute of Molecular Function, 2006, 1-9.
Motonori Tsuji*. Development of the Structure-based Drug Design Systems, HMHC and DSHC. Mol. Sci., 2007, 1, NP004.
Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika. Docking Simulations Suggest that all-trans Retinoic Acid Could Bind to Retinoid X Receptors. J. Comput. Aided Mol. Des., 2015, 29, 975-988.
Motonori Tsuji*. A Ligand-Entry Surface of the Nuclear Receptor Superfamily Consists of the Helix H3 of the Ligand-Binding Domain. J. Mol. Graph. Model., 2015, 62, 262-275.
Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika. Identifying the Receptor Subtype Selectivity of Retinoid X and Retinoic Acid Receptors via Quantum Mechanics. FEBS Open Bio., 2017, 7, 391-396, DOI: 10.1002/2211-5463.12188.
Motonori Tsuji*. Antagonist-Perturbation Mechanism for Activation Function-2 Fixed Motifs: Active Conformation and Docking Mode of Retinoid X Receptor Antagonists. J. Comput. Aided Mol. Des., 2017, 31, 577-585, DOI: 10.1007/s10822-017-0025-6.
Structural Biology
Motonori Tsuji*. Local Motifs Involved in the Canonical Structure of the Ligand-Binding Domain in the Nuclear Receptor Superfamily. J. Struct. Biol., 2014, 185,355-365.
Theoretical Chemistry
Tomohiko Ohwada, Masanobu Uchiyama, Motonori Tsuji, Iwao Okamoto, Koichi Shudo. Orbital Unsymmetrization of Olefins Arising from Non-equivalent Orbital Interactions. s-p Coupling in Bicyclo[2.2.2]octenes. Chem. Pharm. Bull., 1996, 44, 296-306.
Tomohiko Ohwada, Motonori Tsuji, Iwao Okamoto, Koichi Shudo. A Remote Substituent Can Determine Magnitude of Facial Selectivity in Benzobicyclo[2.2.2]octatrienes. Tetrahedron Lett., 1996, 37, 2609-2612.
Motonori Tsuji, Tomohiko Ohwada, Koichi Shudo. A cyclopropyl Group Shows Reverse Facial Selectivity Depending on the Bicyclic Ring System. Tetrahedron Lett., 1997, 38, 6693-6696.
Motonori Tsuji, Tomohiko Ohwada, Koichi Shudo. Facial Selectivities of Benzofluorenes Bearing a Carbonyl, an Olefin, or a Diene Group in Spiro Geometry. p Spiro Substituent Effects. Tetrahedron Lett., 1998, 39, 403-406.
Motonori Tsuji*. On Attempts at Generation of Carboranyl Carbocation. J. Org. Chem., 2003, 68, 9589-9597.
Motonori Tsuji*. Most Stable Conformation of the Cyclopropane Ring Attached at a Carbon Atom in a 1,2-Dicarba-closo-dodecaborane(12) System. J. Org. Chem., 2004, 69, 4063-4074.
Motonori Tsuji*. Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: p Facial Stereoselectivity of Bicyclic and Tricyclic Olefins. Asian J. Org. Chem., 2015, 4, 659-673.
Inorganic Chemistry
Yasuyuki Endo, Kyoko Yaguchi, Motonori Tsuji, Kentaro Yamaguchi, Koichi Shudo. Functionalization of Polymethylcarboranes. Preparation and Reactivity of 2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic Acid. Chem. Pharm. Bull., 1999, 47, 699-701.
Motonori Tsuji*. Synthesis and Biological Activity of Abscisic Acid Mimics. Kyushu Kyoritsu University, Bachelor Thesis, No. 3398, 1-45, 1990.
Motonori Tsuji*. Synthesis and Plant Growth Regulation Activity of N-Acyl-L-proline Derivatives, Kyushu University, Master's Thesis, No. 1964, 1-63, 1992.
Motonori Tsuji*. Orbital Interactions Determining the Facial Selectivity in Bicyclo and Spiro Olefins.The University of Tokyo, Doctoral Dissertation, No. 13735, 1-172,1998.