Last Modified
1 January 2025
Nuclear Receptor Superfamily
Nuclear Receptor
This page is used for the structure-base drug design for the nuclear receptors.
Vitamin A acid (Retinoic Acid)
Structural Biology
Origin of the receptor subtype selectivity via quantum mechanics.
Motonori Tsuji, et. al. FEBS Open Bio. 7, 391-396, 2017, DOI: 10.1002/2211-5463.12188.
Origin of the ligand recognition mechanism in the nuclear receptor superfamily.
Motonori Tsuji. J. Mol. Graph. Model. 62, 262-275, 2015.
Motonori Tsuji. J. Struct. Biol. 185, 355-365, 2014.
Molecular Mechanism
Origin of the agonism and antagonism mechanisms in the nuclear receptors via quantum mechanics.
Motonori Tsuji. J. Comput. Aided Mol. Des. 31, 577-585, 2017, DOI: 10.1007/s10822-017-0025-6.
A proposed molecular mechanism of ATRA for retinoid X receptors.
Motonori Tsuji, et. al. J. Comput. Aided Mol. Des. 29, 975-988, 2015.
Motonori Tsuji. Logical Drug Design for Organic Chemists (Japanese)
Design of Human Retinoid X Receptor Agonists
Design of Human Retinoid X Receptor Antagonists
Homology Modeling
Human Androgen Receptor DNA Binding Domain
Human Mineralocorticoid Receptor Ligand Binding Domain
Freely access our database in which the nuclear hormone receptor crystal structures registered to the Protein Data Bank have been classified on the basis of the structural information.
Analyzed Nuclear Receptor Crystal Structure Database
Ligand Chemistry
Coming Soon
Other Useful Information
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