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   1 January 2020

Theoretical Organic Chemistry Nuclear Receptor Chemistry Structural Bioinformatics Rational Drug Design

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Structure-based Drug Design Systems - SBDD Solutions -


Structure-based Drug Design (SBDD) System



SBDD of Institute of Molecular Function

Invited Lecture

2008/01/11 Motonori Tsuji, Business Research Institute, SBDD Pamphlet (PDF; Japanese)



Motonori Tsuji. On Attempts at Generation of Carboranyl Carbocation. J. Org. Chem., 68, 9589-9597, 2003, DOI: 10.1021/jo035090f.

Motonori Tsuji. Most Stable Conformation of the Cyclopropane Ring Attached at a Carbon Atom in a 1,2-Dicarba-closo-dodecaborane(12) System. J. Org. Chem., 69, 4063-4074, 2004, DOI: 10.1021/jo049854i.

Motonori Tsuji, Rational Drug Design for Organic Chemists, Institute of Molecular Function, 2006.

Motonori Tsuji, Development of the Structure-based Drug Design Systems, HMHC and DSHC. Molecular Science, 1, NP004, 2007.

Science, 319, 624-7, 2008.

Biochemistry, 49, 10647-10655, 2010.

Biochem. Biophys. Res. Commun.,30, 173-177, 2010.

Plant Cell Physiol., 53, 1638-1647, 2012.

Motonori Tsuji. Local Motifs Involved in the Canonical Structure of the Ligand-Binding Domain in the Nuclear Receptor Superfamily. J. Struct. Biol., 185, 355-365, 2014, DOI: org/10.1016/j.jsb.2013.12.007.

Motonori Tsuji. Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: p Facial Stereoselectivity of Bicyclic and Tricyclic Olefins. Asian J. Org. Chem., 4, 659-673, 2015, DOI: 10.1002/ajoc.201500054.

Motonori Tsuji*, et. al. Docking Simulations Suggest that all-trans Retinoic Acid Could Bind to Retinoid X Receptors. J. Comput. Aided Mol. Des., 26, 975-988, 2015, DOI: 10.1007/s10822-015-9869-9.

Motonori Tsuji. A Ligand-Entry Surface of the Nuclear Receptor Superfamily Consists of the Helix H3 of the Ligand-Binding Domain. J. Mol. Graph. Model., 62, 262-275, 2015, DOI: org/10.1016/j.jmgm.2015.10.002.

Motonori Tsuji*, et. al. Identifying the Receptor Subtype Selectivity of Retinoid X and Retinoic Acid Receptors via Quantum Mechanics. FEBS Open Bio., 7, 391-396, 2017, DOI: 10.1002/2211-5463.12188.

Motonori Tsuji. Antagonist-Perturbation Mechanism for Activation Function-2 Fixed Motifs: Active Conformation and Docking Mode of Retinoid X Receptor Antagonists. J. Comput. Aided Mol. Des., 31, 577-585, 2017, DOI: 10.1007/s10822-017-0025-6.





Press Release

2005/07/11 Press Release (PDF, Japanese)

2005/08/22 Press Release (PDF, Japanese)

2006/05/08 Press Release (PDF, Japanese)

2006/11/16 Press Release (PDF, Japanese)

2013/12/23 Press Release (PDF, Japanese)

2015/04/17 Press Release (PDF, Japanese)

2015/11/04 Press Release (PDF, Japanese)

2017/02/15 Press Release (PDF, Japanese)


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