Last Modified
1 January 2024
Structure-based Drug Design Systems - SBDD Solutions -
Structure-based Drug Design (SBDD) System
SBDD of Institute of Molecular Function
Invited Lecture
2008/01/11 Motonori Tsuji, Business Research Institute, SBDD Pamphlet (PDF; Japanese)
Articles
Motonori Tsuji. On Attempts at Generation of Carboranyl Carbocation. J. Org. Chem., 68, 9589-9597, 2003, DOI: 10.1021/jo035090f.
Motonori Tsuji. Most Stable Conformation of the Cyclopropane Ring Attached at a Carbon Atom in a 1,2-Dicarba-closo-dodecaborane(12) System. J. Org. Chem., 69, 4063-4074, 2004, DOI: 10.1021/jo049854i.
Motonori Tsuji, Rational Drug Design for Organic Chemists, Institute of Molecular Function, 2006.
Motonori Tsuji, Development of the Structure-based Drug Design Systems, HMHC and DSHC. Molecular Science, 1, NP004, 2007.
Science, 319, 624-7, 2008.
Biochemistry, 49, 10647-10655, 2010.
Biochem. Biophys. Res. Commun.,30, 173-177, 2010.
Plant Cell Physiol., 53, 1638-1647, 2012.
Motonori Tsuji. Local Motifs Involved in the Canonical Structure of the Ligand-Binding Domain in the Nuclear Receptor Superfamily. J. Struct. Biol., 185, 355-365, 2014, DOI: org/10.1016/j.jsb.2013.12.007.
Motonori Tsuji. Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: p Facial Stereoselectivity of Bicyclic and Tricyclic Olefins. Asian J. Org. Chem., 4, 659-673, 2015, DOI: 10.1002/ajoc.201500054.
Motonori Tsuji*, et. al. Docking Simulations Suggest that all-trans Retinoic Acid Could Bind to Retinoid X Receptors. J. Comput. Aided Mol. Des., 26, 975-988, 2015, DOI: 10.1007/s10822-015-9869-9.
Motonori Tsuji. A Ligand-Entry Surface of the Nuclear Receptor Superfamily Consists of the Helix H3 of the Ligand-Binding Domain. J. Mol. Graph. Model., 62, 262-275, 2015, DOI: org/10.1016/j.jmgm.2015.10.002.
Motonori Tsuji*, et. al. Identifying the Receptor Subtype Selectivity of Retinoid X and Retinoic Acid Receptors via Quantum Mechanics. FEBS Open Bio., 7, 391-396, 2017, DOI: 10.1002/2211-5463.12188.
Motonori Tsuji. Antagonist-Perturbation Mechanism for Activation Function-2 Fixed Motifs: Active Conformation and Docking Mode of Retinoid X Receptor Antagonists. J. Comput. Aided Mol. Des., 31, 577-585, 2017, DOI: 10.1007/s10822-017-0025-6.
Motonori Tsuji. Potential Anti-SARS-CoV-2 Drug Candidates Identified through Virtual Screening of the ChEMBL Database for Compounds That Target the Main Coronavirus Protease. FEBS Open Bio., 10, 995-1004, 2020,DOI:10.1002/2211-5463.12875.
Motonori Tsuji. Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from cryo-EM Experiments with High Binding Affinity. Int. J. Mol. Sci. 23, 11009, 2022.DOI: 10.3390/ijms231911009.
Patent
Motonori Tsuji. SEITAIKOUBUNSHI NIOKERU SOUGOSAYOUBUI NO YOSOKUHOUHOU, JP 2007-299125, 2006.
Press Release
2005/07/11 Press Release (PDF, Japanese)
2005/08/22 Press Release (PDF, Japanese)
2006/05/08 Press Release (PDF, Japanese)
2006/11/16 Press Release (PDF, Japanese)
2013/12/23 Press Release (PDF, Japanese)
2015/04/17 Press Release (PDF, Japanese)
2015/11/04 Press Release (PDF, Japanese)
2017/02/15 Press Release (PDF, Japanese)
2020/05/08 Press Release
2021/10/04 Press Release
2022/09/21 Press Release
Collaborative Research
There are many experiences for 15 years.