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   1 January 2020

Theoretical Organic Chemistry Nuclear Receptor Chemistry Structural Bioinformatics Rational Drug Design

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Synthesis and Activity of Carboranamine Derivatives as an Anti-Influenza A Virus Active Compound

 

The adamanthylamine (Amantadine) and its derivative, Remantadine, show an anti-influenza A virus activity. The mechanism of this activity is considered as destruction of the virus cell membrane. The following figures show a typical anti-influenza A active compound.
 

Amantadine                                 Reamantadine

Influenza A virus active compounds

 

The following carboranamine derivatives were synthesized and their anti-influenza activity were estimated.

 

 

Results:

Unfortunately, all of these compounds did not show an anti-influenza virus activity.

 

From experimental notebook at 1998.

Motonori Tsuji

 

 

 

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